The George F. Allison House is a historic house located at 418 West Duval Street in Live Oak, Florida, United States.

It is locally significant as the home of George F. Allison, who was a pioneering Live Oak businessman during the city's formative commercial years as well as being a fine example of Colonial Revival architecture in the area.

The large, two-story, Colonial Revival style house was given its present appearance when it was remodeled in 1927 after 40% of the rear was damaged by a fire on New Years Day.

On April 20, 1995, it was added to the U.S. National Register of Historic Places.

This article about a property in Suwannee County, Florida on the National Register of Historic Places is a stub.