For a couple of years he worked for the U.S. Lake Survey and then a Mississippi River improvement project, before joining Washburn Observatory as the assistant director in 1879.

[3] He was appointed professor at Ohio State University in 1887, where he taught mathematics and astronomy, and he took over directorship of the Washburn Observatory.

[2] On June 12, 1894, he was married to Esther Cecile Everett, and the couple had a daughter, Mary Cecelia Comstock Carey.

[2] He helped organize the American Astronomical Society in 1897, serving first as secretary and later as vice president.

[4] George Comstock died in Madison on May 11, 1934, and was buried at Forest Hill Cemetery.