George H. Sanford (December 14, 1836 – November 25, 1871) was an American politician from New York.
At age twelve, he became a clerk in a store in Glens Falls while attending the common schools in winter.
In winter, he attended school, or went lumbering in Genesee County, New York, and Potter County, Pennsylvania; and attended for one year Rensselaer Polytechnic Institute.
About 1857, he removed to Syracuse, and became a merchant, engaging in the lumber and salt trade.
He was a delegate to the 1864 Democratic National Convention; Supervisor of the Town of Verona in 1865 and 1866; a member of the New York State Assembly (Oneida County, 3rd D.) in 1867; a delegate to the 1868 Democratic National Convention; and a member of the New York State Senate (19th D.) in 1870 and 1871.