George Holcombe (March 1786 – January 14, 1828) was an American physician and politician who served as a United States representative from New Jersey.
Born in what was then Amwell Township (now in part of Lambertville in Hunterdon County, New Jersey) he completed preparatory studies and graduated from Princeton College in 1805.
He attended the medical department of the University of Pennsylvania at Philadelphia and later studied medicine in Trenton.
Holcombe was granted a license by the Medical Society of New Jersey and practiced medicine in Allentown from 1808 to 1815.
Holcombe held several local offices and was a member of the New Jersey General Assembly in 1815 and 1816.