[2][3] Having made his way through all of the youth levels of the amateur Antony Football Evolution, George Ilenikhena joined the professional club of Amiens that was just relegated to Ligue 2, for the 2021–22 season.
[5][7][8] Ilenikhena made his professional debut for the Amiens SC on 19 November 2022, during a 10–0 home Coupe de France win to the Aiglon du Lamentin.
[13] On 29 June 2023, Ilenikhena signed for Belgian Pro League champions, Royal Antwerp, on a four-year deal,[14] for a reported fee of €6 million.
[16] Later that year, on 13 December, he scored his first Champions League goal in the 92nd minute of stoppage time, securing a 3–2 victory against Barcelona to be his club's first ever win in the competition.
[8][19] Ilenikhena is a quick centre-forward,[8] Philippe Hinschberger, the coach of his debut with Amiens, describes him as a strong left-footed player, with an outstanding ability to attack the depth of the field.