One of the earliest and among the most prominent Syrian Christians from Kerala to join the freedom struggle, George's working life in Madurai and is remembered for his role in the Home Rule agitation and the Vaikom Satyagraha and for his editorship of Motilal Nehru's The Independent and Mahatma Gandhi's Young India.
In 1917, aged 29, George was invited by Annie Besant to go to England along with her, Syed Hussain and BV Narasimhan to talk about Home Rule there.
The British however foiled this bid, arresting them when the ship Besant had chartered reached Gibraltar, Subsequently, deporting them back to India.
[3][5] George played an important role in setting up the trade union movement in Madurai to organise the textile mill workers there.
[3][6] George edited the Nehrus' Allahabad based newspaper The Independent during 1920-21 until his arrest on charges of sedition and the subsequent closure of the paper.
[13] Later, when Kamaraj was implicated in Virudhunagar Conspiracy Case in 1933, George and Varadarajulu Naidu argued on his behalf and succeeded in exonerating him of all charges.
He fought for them in the courts and wrote extensively in the newspapers against the act and came to be called Rosapoo Durai by the grateful Kallars who continue to pay homage to him on his death anniversary.