Israel George "Izzy" Levene (May 1, 1885 – November 12, 1930) was an American college football player and coach.

Levene played college football at the University of Pennsylvania, and was named an All-American in 1905 and 1906.

Levene was known for being a football player who worked hard to help out his team, as well as one of the first good pass catching ends.

His worst season came in 1909, when his team went 1–6–2, with the one win coming against Transylvania University.

In 1922, Levene served as the head coach at Wake Forest.