The George Randolph Frisbee Jr. House is a historic house located at 2125 Palmetto Street in Middleburg, Florida.

It is locally significant as an excellent example of late 19th century vernacular building trends and also as one of the few buildings dating from the early developmental period of the community.

It is a two-story, Frame Vernacular building, with an L-shaped floor plan.

The symmetrical main facade is dominated by a two-story, hip roofed porch with chamfered post supports and a balustrade.

It was added to the National Register of Historic Places on March 9, 1990.