The school has a strong record in athletics, celebrating state championships in numerous sports.

The old Clark County High School boys' basketball team won the 1951 Kentucky High School Athletic Association (KHSAA) state title under head coach Letcher Norton.

The most recent addition to GRC Athletics is the boys' and girls' swim team, which competed in its first season during the 2005–2006 school year.

The squad also typically attends the NCA competition in Dallas, Texas, where they have placed numerous times as well.

The last one is black and has the word "Cardinals" going horizontally across the chest and three red stripes going down the rib cage and on the body suite.

In 2014, the George Rogers Clark Varsity squad earned the title of Kentucky State Champions.

While it is not a sport recognized by the KHSAA, cheerleading is popular and very competitive at George Rogers Clark.

In 2006, the cheerleading team captured its fourth straight Kentucky Association of Prep Organization Sponsors (KAPOS) state championship.

In 2019 and 2018, the school placed second at the region competition, with several students and their quick recall team advancing to state.

GRC's Gay-Straight Alliance (GSA) has allowed students to feel more safe, and participated in the Day of Silence in 2021 and 2022.