Trained as a lawyer, Della was appointed to the Maryland Senate in 1939 to represent a southern and southwestern district in Baltimore and served until his retirement from politics.
By 1936, Della had passed the Maryland Bar and begun to practice law, and the same year he was wed to Agnes H. Mattare, with whom he had three children, George, Mary, and Howard.
In 1959 the Boumi Temple of the Shrine, part of the Freemason organization commonly referred to as the Shriners, made him potentate.
[2] Following his retirement, Della was hired as a lobbyist in 1967 by the Baltimore Gas and Electric Company, (now Constellation Energy, part of the larger regional utility conglomerate Exelon).
[2] His son George W. Della, Jr. followed in his father's footsteps, winning election as a Senator from Baltimore's 47th district in 1983 and remaining state Senator in a redistricted 46th district in 2003 until his Democratic Party primary defeat after 28 years in the upper chamber at the Maryland State House in September 2010.