As founding president of RAMIT (Research in Medical Informatics and Telematics), he has been involved in both European and International Research and Development projects (+120), as well as in Standardisation activities: for seven years, De Moor acted as the Founding Chairman of CEN/TC251, the official Technical Committee on standardisation in health informatics in Europe.
As a result of the conducted research, De Moor has been founding or co-founding a number of spin-off companies mainly active in eHealth, including the domain of privacy protection (e.g. MediBridge, Custodix).
De Moor is also Head of the Clinical Pathology Laboratory in the Saint Elisabeth Hospital in Zottegem, Belgium.
He is member of the board of the Belgian Health Care Knowledge Centre (KCE, Federaal Kenniscentrum Gezondheidszorg).
De Moor chairs in Belgium and in Europe a number of official Committees related to ICT in Health or to Laboratory Medicine.