It travels from the Alabama state line southwest of Menlo, where the roadway continues as Cherokee County Road 99, northeastward through Broomtown Valley at the foot of Lookout Mountain.

SR 337 begins at the Alabama state line, southwest of Menlo, where the roadway continues as Cherokee County Route 99 (CR 99).

After leaving Menlo, SR 337 travels to the northeast through rural areas of Chattooga and Walker counties.

Approximately 500 feet (150 m) after the intersection with South Industrial Loop, the highway enters the southwestern part of the city limits of LaFayette.

It entered the state farther to the north than it currently does, traveling along Jamestown Road, and through the western part of Menlo; then, it continued to LaFayette as it does today.