Throughout much of this segment, US 23/SR 19 has standard rural Georgia surroundings, with its mix of wooded areas and local farmland.

Nearing Hazlehurst, the routes brushes by a dirt road that used to be an old segment of Alma Highway before the continuing into the southern terminus of US 23 Bus./SR 135 Conn., while US 23/SR 19 turns right onto Larry Contos Boulevard, taking part of US 221 Truck/SR 135 Truck with it.

The route officially enters the Hazlehurst City Limits between Currie Street and a railroad crossing for a former Southern Railway line (now the Norfolk Southern Railway's Brunswick District).

Larry Contos Boulevard ends at US 341/SR 27 (a divided four-lane highway Designated the Golden Isles Parkway), and US 23/SR 19 turns northwest along this route.

The first notable site along this segment is the combined Hazlehurst Fire Department and the Hazlehurst — Jeff Davis County Chamber of Commerce building on the northeast corner of Oak Street.

North of there, it resumes its rural characteristics and has an intersection with SR 46 and later the first of many interchanges with Interstate 16 (I-16), this one specifically at exit 54.

In Dublin, SR 19 briefly travels concurrent with US 441 then turns west to join US 80/SR 26.

Later, in Macon, SR 19 leaves US 80/SR 87, and at exit 1A, on I-16 turns south on a wrong-way concurrency with US 129/SR 49.

Highways, are the only segments that are part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility, and defense: SR 19 was established at least as early as 1919 from Glenwood to Barnesville.

[8][9] Between April 1949 and August 1950, US 23 was designated on two segments of SR 19: from north of Alma to Lumber City and from east of Macon to southeast of Forsyth.

[17][18] In 1998, the Georgia state legislature passed a resolution designating a portion of SR 19 in Macon as "Duane Allman Boulevard" and a bridge thereon as the "Raymond Berry Oakley III Bridge" in honor and remembrance of Duane Allman and Berry Oakley, late founding members of The Allman Brothers Band.

was a business route of SR 19 that existed completely within the city limits of Hazlehurst.

State Route 19 Connector (SR 19 Conn.) is a 0.2-mile-long (0.32 km) connector route that exists entirely within the city limits of Hazlehust in the north central part of Jeff Davis County, and is known as East Coffee Street for its entire length.

It begins at an intersection with US 221/SR 135 (South Tallahassee Street) in the central part of Hazlehurst.

It replaced SR 148 from northeast of Bolingbroke to east of the community, with this segment under construction.