State Route 220 (SR 220) is a 18.8-mile-long (30.3 km) state highway that runs southwest-to-northeast in a semicircle completely within Lincoln county in the east-central part of the U.S. state of Georgia.

SR 220 begins at an intersection with US 378/SR 47 (Double Branches Road) southwest of Lincolnton.

It heads southeast to an intersection with SR 43 (Thomson Highway), which is located south of Lincolnton.

The highway travels northeast until it reaches a second intersection with SR 47 (Augusta Highway, located southeast of Lincolnton).

SR 220 continue to the northeast and turns to the north-northeast, crosses Strom Thurmond Lake, and then meets its northeastern terminus, an intersection with US 378/SR 43 (Coach Jimmy Smith Highway).