The portion from southwest of Gordon to north-northeast of Ivey, as well as the later roadway that was built from that point to southeast of Milledgeville became concurrent with SR 540, the state highway designation for the Fall Line Freeway (FLF; a highway that connects Columbus with Augusta), and was replaced in 2019 by an extended SR 540.

At this intersection, it began a concurrency with SR 540 as part of the Fall Line Freeway.

After a curve to the northeast, they crossed over Little Commissioner Creek and some railroad tracks of Norfolk Southern Railway.

After leaving the city limits of Gordon, they intersected SR 18 (Gray Highway).

They traveled through the town of Ivey, where they crossed over Beaver Creek and skirted past Brooks Lake.

Almost immediately, SR 243 entered Baldwin County and crossed a Central of Georgia Railway line.

[9][10] The segment between the Scottsboro and Sandersville areas was completed and opened to traffic in October 2016.