Except for the northern part of the highway, from Savannah to Port Wentworth, it is concurrent with U.S. Route 17 (US 17) for its entire length.

Within the city, US 17/SR 25 follows four-lane divided Bedell Avenue, which intersects SR 25 Spur (10th Street), a connector between the center of town and I-95.

The highway intersects and begins to travel concurrently with SR 110 (4th Street) within the Woodbine Historic District.

US 17/SR 25 curves east and enters Glynn County by crossing the Little Satilla River at Spring Bluff.

The concurrency curves north and within a suburban area has a four-way intersection with US 82/SR 520 (South Georgia Parkway) and the southern terminus of SR 303 (Blythe Island Highway).

US 17/SR 25 turns east onto four-lane divided South Georgia Parkway, here also known as Jekyll Island Road, to travel concurrently with US 82/SR 520.

The highways gain a third lane southbound at US 25/SR 25 Conn. and a third lane northbound at the F.J. Torras Causeway to St. Simons Island, which is unsigned as SR 25 Spur E. US 17/SR 25 crosses Cypress Mill Creek and leaves the city limits just south of its directional intersection with the southern terminus of SR 25 Spur (Golden Isles Parkway), which connects US 17/SR 25 with I-95.

US 17/SR 25 reduces to two lanes just north of Chapel Crossing Road to the east of the Federal Law Enforcement Training Center.

The highways re-enter a rural area as they travel to the east of Brunswick Golden Isles Airport.

US 17/SR 25 crosses a pair of swamps around the hamlet of Ardick and intersects SR 99 (Ridge Road) again at Eulonia.

US 17/SR 25 temporarily expands to four lanes between its crossing of the Riceboro Southern Railway, which is part of the former Seaboard Air Line corridor, and its intersection with the eastern terminus of SR 119 (E.B.

The highways meet SR 204 (Abercorn Expressway) at a diamond interchange in the suburb of Georgetown then crosses the Little Ogeechee River.

Immediately after is a partial interchange with West Lathrop Avenue, which serves the Georgia Ports Authority's Ocean Terminal.

They pass the Mary Calder Golf Course before an interchange with the northern terminus of SR 26 Conn. (Burnsed Boulevard).

The highway then intersects the eastern terminus of SR 30 (Bonny Bridge Road) and then curves to the northeast.

It crosses over the Savannah River on the James P. Houlihan Memorial Bridge and travels on Onslow Island.

At this same time, SR 27 was established on a westward curve from St. Marys to a point northwest of Brunswick, following parts of the current path of US 17/SR 25 in this area.

In addition, an unnumbered road was built from SR 21 north-northwest of Savannah east-northeast to the South Carolina state line.

US 17 and SR 25 were extended north-northwest from Savannah to the previously-unnumbered road and then east-northeast to the South Carolina state line.

At this time, the path of SR 25 Spur in Savannah was utilized as the northbound lanes of US 17/SR 25, while US 17/SR 25 southbound used the previous routing.

[39][40] In 1995, the path of US 17 between Savannah and Hardeeville, South Carolina was shifted to the southeast, onto I-16 and SR 404 Spur, thus replacing US 17 Alt./SR 25 Alt.

Just before an intersection with the southern terminus of Pine Forest Drive, which leads to Woodbine Elementary School, it curves to the southeast.

After a curve back to the east-southeast, it meets its eastern terminus, an interchange with Interstate 95 (I-95) just southeast of the city.

It begins at an intersection with US 17/SR 25 (Glynn Avenue) and the southern terminus of Stacy Street in the eastern part of Brunswick.

At an intersection with SR 303 (Cypress Mill Road), it briefly leaves the city limits of Brunswick and enters Country Club Estates.

In 1966, it was established on West Lathrope Avenue from US 17/US 80/SR 25/SR 26 (Bay Street) northeast to the Georgia Ports Authority.

East-southeast of an intersection with East Lathrop Avenue, it travels on the Dorothy Barnes Pelote Bridge, which crosses over some railroad tracks of Norfolk Southern Railway, travels under the Talmadge Memorial Bridge (carrying US 17/SR 404 Spur), and crosses over the Springfield Canal.

Within the first two blocks, it passes by the First African Baptist Church and the Ships of the Sea Maritime Museum and then turns right onto Oglethorpe Avenue.

It travels to the west-northwest and passes the Chatham Area Transit bus station between Ann Street and Fahm Avenue.

A short distance later, the highway has a partial interchange with US 17 north/SR 404 Spur north (Talmadge Memorial Bridge).