The highway connects the Eastman area with the south-central part of Bulloch County.

SR 46 begins at an intersection with US 341/SR 27 (Hawkinsville Highway), just west of Eastman, in Dodge County.

These three highways head concurrently to the northeast for just over 1,000 feet (300 m), then curve to the east to enter Eastman.

At Ogden Street, they head southeast for a short while, then turn left on 5th Avenue.

The two highways head concurrently to the northeast past an intersection with US 319/US 441/SR 31, and then curve to the east-southeast.

The highway passes by Wildwood Lake and intersects SR 86, just before leaving the county.

They cross over the Ohoopee River and have an interchange with I-16 before SR 46 splits off and begins to parallel the interstate for the rest of its length.

After the highway leaves Metter, it travels through Pulaski before entering Bulloch County.

The route is completely inside the main part of the city limits of Eastman, and is known as Page Street for its entire length.

It begins at an intersection with the SR 46 mainline (5th Avenue), just northeast of the downtown part of Eastman.

The highway heads northeast for one block until it meets its northern terminus, an intersection with SR 117 (Anson Avenue).