In the U.S. state of Georgia, US 25 is as a 190.0-mile-long (305.8 km) highway that travels south to north in the eastern part of the state, near the Atlantic Ocean, serving Statesboro and the Brunswick and Augusta metropolitan areas on its path from Brunswick to South Carolina at the Savannah River.

Its routing travels through portions of Glynn, Wayne, Long, Tattnall, Evans, Bulloch, Jenkins, Burke, and Richmond counties.

This highway is being considered for inclusion as part of I-3, which is ultimately planned to stretch from Savannah to Knoxville, Tennessee.

On the northern edge of the park, they intersect Newcastle Street and turn left, back to the north.

They cross over Burnett Creek and travel through Pyles Marsh, before curving back to the north.

The highways travel through Pennick and Zuta, before passing to the southeast of Berry Lake.

After traveling through Grangerville, Pendarvis, and Gardi, they make a slight westward jog in Odessa; then, they cross over Ponholloway Creek, before entering Jesup.

In town, US 25 splits off from US 341/SR 27 (East Cherry Street) to the north and intersects US 301/SR 23, with which US 25 begins traveling concurrently.

Immediately afterward, the five highways travel to the north and leave the city limits.

After passing to the east of Durrence Pond, just west of Midway, US 25/US 301/SR 73 cross into Evans County.

After a westward jog past Richards Pond, the highways curve to a due north routing and enter Claxton.

They pass just to the west of Georgia Southern University and skirt along the eastern edge of W. Jones Lane Memorial Park.

They curve to the north-northeast and cross over Little Lotts Creek before intersecting SR 67 (Fair Road).

Approximately two miles (3.2 km) later, immediately after traveling through Emmalane, they intersect SR 23, which also joins the concurrency.

At Union Camp Logging Road, the four highways curve to the northeast and cross over the Ogeechee River.

On the northwestern edge of the park, they pass Millen Airport and curve back north, passing Magnolia View Lake and Perkins; they curve once again to the north and enter Burke County.

[3] The concurrency travels west of Munnerlyn, passing Jenkins Lake, makes a slight westward jog, and curves due north before curving back to the northwest in Idlewood and passing Burke County Airport.

The mainline highways turn to the right and curve back to the north and have an interchange with the bypass route.

Just before entering Waynesboro the roadway passes west of the Burke County campus of Augusta Technical College.

They cross over Walnut Branch and Brier Creek, before traveling to the west of Stockton Pond.

Approximately four miles (6.4 km) later, the highways cross over McBean Creek into Richmond County and the city limits of Augusta.

[3] Just before passing the Pointe South Golf Club, US 25/SR 121 begin to travel along the Hephzibah–Augusta city line.

The two highways cross over Butler Creek and make a gradual winding path to an interchange with I-520 (Bobby Jones Expressway), passing to the west of Foss Park and the Charles B. Webster Detention Center and to the east of Rollins Elementary School and Sego Middle School along the way.

It curves to the northeast and intersects Tubman Home Road and SR 56 (Mike Padgett Highway).

The six-highway concurrency continue north to an intersection with Molly Pond Road and Doug Barnard Parkway (former SR 56 Spur).

A short distance later, they pass the Old Medical College and the Old Government House, then an interchange with US 25 Business (US 25 Bus.

At the state line, SR 10 ends, while US 1/US 25/US 78/US 278/SR 121 (Continues as South Carolina Highway 121) curves to the northeast toward North Augusta.

[3] From its southern, in Brunswick,[4] to Ludowici[5] and from I-16, south-southwest of Statesboro[5] to its northern terminus, at the South Carolina state line on the northeastern edge of Augusta[6] are included as part of the National Highway System, a system of routes determined to be the most important for the nation's economy, mobility, and defense.

Highways in Augusta were rerouted on a bypass to the east of the main part of downtown.

This highway is being considered for inclusion as part of I-3, which is ultimately planned to stretch from Savannah to Knoxville, Tennessee.