It and SR 59 serve to connect Commerce and Toccoa.

About 1,000 feet (300 m) after its southern terminus, SR 63 has an interchange with Interstate 85 (I-85) in rural Banks County.

The two highways form a concurrency to the north-northeast.

Just before entering Toccoa, SR 63 has an intersection with SR 145 before traveling northwest and curve to the north until it meets its northern terminus, an intersection with US 123/SR 184/SR 365 in downtown Toccoa.

This intersection also marks the northern terminus of SR 106.