In honor of the late founder of Chick-fil-A, the majority of the route is signed as the S. Truett Cathy Highway.

Now traveling east, the road crosses over Interstate 75 (I-75; exit 221) after expanding to a divided four-lane highway.

The route enters the city limits of McDonough, reducing back to a two-lane road without bike lanes just before an at-grade crossing with another Norfolk Southern track.

From this crossing west to an intersection with McDonough Parkway, Jonesboro Road is dedicated as the SFC John Beale Hero's Highway.

At the town square of the McDonough Historic District, Jonesboro Street comes to its eastern terminus at an intersection with US 23/SR 20/SR 42/SR 81.

[5] The highway existed as early as 1830 when white settlers began to occupy the area previously held by the Creek people after the 1821 and 1825 Treaties of Indian Springs,[original research?]

[7] During the American Civil War the road and its surroundings was the site of the Battle of Lovejoy's Station that took place on August 20, 1864.

[14] On June 2, 2010 a mile long section of the road in McDonough was dedicated in honor of Sergeant John Beale, an Army National Guardsman that was killed in Afghanistan.

The reconfiguration project extended the divided highway all the way to its eastern terminus at the McDonough town square and improved intersections along the corridor.

A major objective of the project was to improve the Norfolk and Southern rail crossing for both pedestrian and vehicle traffic.

[17] Georgia DOT has long-range plans to widen the full length of the highway to four travel lanes.