It exists in two distinct sections, split by the Florida state line, traveling west–east within portions of Lowndes, Echols, Clinch, and Charlton counties.

It curves back to the east-southeast and crosses over the Alapaha River on the western edge of Statenville.

On the northwestern corner of the intersection of Walker Circle, it passes the U.S. Post Office for the community.

Just west of an intersection with the northern terminus of Barnes Road, it curves back to the east-southeast.

A short distance after an intersection with the southern terminus of Will Rewis Road, it curves to the southeast.

It then crosses over Suwannoochee Creek on the PFC Don Manac Memorial Bridge into Clinch County.

A short distance later,US 441/SR 89 splits off to the south-southeast just before an intersection with the southern terminus of SR 177 (Okefenokee Trail).

[1] The route resumes at the spot where SR 2 meets the Georgia state line, west of Moniac, on the southeastern edge of the Okefenokee National Wildlife Refuge, at a crossing over the St. Marys River within Charlton County.

On the southwestern corner of an intersection with the northern terminus of Cherokee Way is the Charlton County – St. George Recreation Department.

It continues to the east-northeast and leaves St. George just before it reaches its eastern terminus, a second instance with the Florida State line.