He played college football at NC State, and was selected by the Indianapolis Colts in the fourth round of the 2018 NFL draft.

At the Atlantic Coast Conference (ACC) outdoor track and field championships he placed third in the 100 meters, with a personal-best time of 10.34 seconds.

[11][12] Hines' 4.38 second 40-yard dash was the fastest among 2018 NFL Draft Combine running backs.

[17] In the following game, a 21–9 victory over the Washington Redskins, Hines scored his first professional touchdown, an eight-yard rush.

[20] In the Wild Card Round against the Texans, he played but recorded no meaningful statistics in his playoff debut, a 21–7 victory.

[32] On November 1, 2022, the Colts traded Hines to the Buffalo Bills in exchange for running back Zack Moss and a conditional sixth-round pick in the 2023 NFL draft.

[33] In Week 18 against the New England Patriots, Hines returned two kickoffs for touchdowns, becoming the eleventh NFL player to do so in a single game in the 35–23 win.

[35] Hines missed the entire 2023 season after sustaining a leg injury in a personal watercraft accident during the offseason, in which he and another jet ski driver collided with each other.

[40] Hines' twin sister, Nyah, competed for the NC State track and field team.