[1] It was the nation's fifteenth appearance at the Summer Olympics, having taken part in all but three editions since its debut (as the Gold Coast) in 1952.

Ghanaian athletes achieved the entry standards, either by qualifying time or by world ranking, in the following track and field events (up to a maximum of 3 athletes in each event):[2][3] Ghana entered three boxers into the Olympic tournament.

London 2012 Olympian Sulemanu Tetteh (men's flyweight) and rookie Samuel Takyi (men's featherweight) scored a box-off victory each to secure places in their respective weight divisions at the 2020 African Qualification Tournament in Diamniadio, Senegal.

Kwadjo Anani accepted a continental berth from Africa as the nation's top-ranked judoka outside of direct qualifying position in the IJF World Ranking List of June 28, 2021.

Rio 2016 Olympian Christian Amoah topped the list of weightlifters from Africa in the men's 96 kg category based on the IWF Absolute Continental Rankings.