In 1925 Mihoc enrolled at the University of Bucharest, Faculty of Sciences, and was awarded his degree in mathematics in June 1928.
[3] In 1930 he was appointed professor in the School of Statistics, Actuarial Studies, and Calculation, which had been established that year (it later became an Institute).
On April 28, 1934, he earned his Doctorate in Mathematics from the University of Bucharest, in front of a commission consisting of Dimitrie Pompeiu, as chairman, Anton Davidoglu, and Onicescu.
The subject of his thesis, written under the direction of Onicescu, was On the general properties of interdependent statistical variables.
[3] From 1937, Mihoc went to the University of Bucharest as assistant to Octav Onicescu, first at mechanics, then at algebra and probabilities calculation (1937–1942).
Mihoc supervised 6 Ph.D. students at the University of Bucharest, including Marius Iosifescu and Radu Theodorescu [de].