[1] The film stars Chris Evans, Ana de Armas, Adrien Brody, Mike Moh, Amy Sedaris, Tim Blake Nelson, Marwan Kenzari, and Anna Deavere Smith.

Cole's sister suspects she is "ghosting" him, but their parents convince him to surprise Sadie in London, after locating her via a tracker on his inhaler that he accidentally left in her bag.

After a chase through the Khyber Pass, they escape Cole's captors, who are working for Leveque, a disgraced French Intelligence agent selling a stolen bioweapon called "Aztec", for which he needs the passcode.

At CIA headquarters, Sadie is suspended for losing Aztec and tries to apologize for putting Cole in danger, but he is hurt by her commitment to her mission above all else.

In August 2021, Chris Evans and Scarlett Johansson entered negotiations to star in Ghosted, a film pitched by screenwriters Paul Wernick and Rhett Reese to Skydance Media, with Dexter Fletcher attached to direct.

[2][3] In December 2021, Johansson had to exit the film due to a scheduling conflict, leading to Ana de Armas being cast in her place.

[6] Principal photography took place from February to May 2022[7][8] at Tallulah Falls Lake in Tallulah Gorge State Park, Georgia; North Park Square, Marietta, Georgia; Chesapeake and Ohio Canal between Thomas Jefferson and 31st Street in Georgetown, the Lincoln Book Tower, Ford's Theatre and the Kennedy Center for the Performing Arts, all in Washington D.C.[9] Scenes in the Khyber Pass mountains were filmed in New Mexico, while the city of Mingora, Pakistan, was filmed on a set in Atlanta.

[10] According to a Samba TV research panel of 3.1 million smart television households who tuned in for at least one minute, Ghosted drew in 328,500 viewers in the first two days, and is the most watched film debut in Apple TV+ history.

The website's consensus reads: "Listlessly wafting between action, comedy, and romance without ever solidifying into a satisfying whole, Ghosted earns a chorus of boos.