His literary career though started with Sindhi short story took many turns whereby he contributed a number of literary and scholarly articles on varied topics including history of Sindhi language, culture, religion, biographies of prominent personalities, and many more.
His father was a prominent educationist of his time and therefore contributed towards his literary grooming in the early years of his life.
Ghulam Rabbani Agro acquired his primary education from the local schools, and then proceeded to SMA College Karachi, where he completed his B.A in English Literature in 1957.
He was founding editor of Quarterly Gul Phul, a popular children's magazine published by Sindhi Adabi Board.
Mr. Agro was also chief editor of literary magazine “Adabiyat” published by Pakistan Academy of Letters.
Ghulam Rabbani Agro joined Sindhi Adabi Board (SAB) in 1957 as assistant secretary.
During his thirty years career at SAB, he undertook more than 300 various publishing projects on Sindh's literature, culture, language and history.
Mr. Agro's stories' subject matter was the hardships and atrocities faced by the oppressed and subjugated class of sindhi society- the haris (peasants).
His story "Bure hin Bhambhore Mae" was first translated into English as "The deluge", by Hashu Kewal Ramani.
The story got international recognition and was subsequently translated into many languages such as German, Hindi, Tamil, Chinese, and Polish.
The Rajah of Alra called Mahraj, whose kingdom was situated between Kashmir and Punjab, requested Amir Abdullah bin Umar, the ruler of al-Mansura, to send him someone to translate the Quran into his language around AD 882.
However, few political groups in West Pakistan wanted to curb these demands of Bengalis and therefore hatched a conspiracy to amalgamate the four provinces Sindh, Balochistan, NWFP and the Punjab as one unit.
Some of prominent names who waged a war against Ayub Khan's Martial Law and against one unit were Muhammad Ibrahim Joyo, Ghulam Rabbani Agro, Shaikh Ayaz, Rasheed Bhatti, Tanveer Abbasi, and Sirajul Haq Memon etc.
These writers and poets raised their voice through their writings and pressurized the Ayub government to restore the status of Sindhi language.
Ghulam Rabbani Agro received a number of awards, shields and honors in recognition of his services to literature.