Mian Muhammad Ghulam Shah Kalhoro (1724 – 1772, Sindhi: مياں محمد غلام شاه ڪلهوڙو) was a member of the Kalhora dynasty who, in 1757, was enthroned as the 3rd Nawab of Sindh by tribal chiefs of Kalhora, replacing his brother Mian Muradyab Kalhoro.

He was recognized and bestowed upon the titles of Shah Wardi Khan and Samsam-ud-Daulah by the Afghan emperor Ahmad Shah Durrani.

He was able to bring stability in Sindh after the rule of Noor Mohammad Kalhoro; he reorganized the country and defeated the Marathas and their permanent vassal the Rao of Kutch near the Thar Desert and returned victoriously.

[1] The tomb of Ghulam Shah Kalhoro is situated in Hyderabad, Sindh.

[2] This Indian biographical article is a stub.