The dynasty governed much of Sindh and parts of Kutch (present-day Gujarat, India) between 1701 and 1783 from their capital of Khudabad, before shifting to Hyderabad from 1768 onwards.

[2] They were assigned to hold authority by the Mughal Grand Vizier Mirza Ghazi Beg.

[citation needed] Kalhora governance of Sindh began around the start of the 18th century when Yar Muhammad Kalhoro was invested with title of Khuda Yar Khan and was made subedar of Upper Sindh by royal decree of the Mughals.

Later, after his death, his son was additionally appointed subedar of Sehwan and thus oversaw most of Sindh.

Mian Ghulam Shah Kalhoro reorganised and consolidated his power, but his son lost control of Sindh and was overthrown by Talpurs amirs.