Methuselah-like 5 is a G protein coupled receptor (GPCR) that is essential for cardiac development in Drosophila.
[1] G-protein-coupled-receptors (GPCR) have a characteristic arrangement of seven transmembrane portions that culminate in an extracellular N-terminus and intracellular C-terminus.
[3] GPCRs activation is facilitated by the g-proteins Gα, Gβ, and Gγ.
[3] Drosophila have a relatively small number of G-proteins, making them a useful model for the study of GPCR outcomes.
[4] Genes important for cardiac development in Drosophila include NK2, MEF2, GATA, Tbx, and Hand.