[1] Fragomeni bounced back by winning the vacant European Union cruiserweight title with a unanimous decision (UD) over Vincenzo Rossitto on 31 July 2007, and went on to make two successful defences.

On 24 October 2008, Fragomeni won the vacant WBC cruiserweight title after a sixth-round technical decision against Rudolf Kraj.

[2] His first defence of the title, against Krzysztof Włodarczyk on 16 May 2009, ended in a split draw despite Fragomeni suffering two knockdowns but only one of them being considered legal by the referee.

[3] Fragomeni was not as fortunate in his next defence, on 21 November 2009, when he lost a very close majority decision to undefeated former light-heavyweight world champion Zsolt Erdei.

This time, Fragomeni was forced to retire in his corner after six largely one-sided rounds due to a cut which was caused by an accidental punch from Włodarczyk on the break.