In 1715 he became the first person to have an account of the practice of inoculation published by the Royal Society.
[3][4] He studied law and then medicine at the University of Padua before qualifying as a physician.
In Moscow he was appointed physician to the Russian Tsar Peter the Great.
[citation needed] He returned to Smyrna for the second time and resided there as the Venetian Consul as well as practising physician.
[citation needed] Together with another Greek doctor called Emmanuel Timoni, he introduced variolation to Western Europe through their writing from Constantinople.