Giacomo Tedesco started his professional career with his hometown club U.S. Città di Palermo in 1994.
Later in 2003, he was sold to Serie A side Reggina Calcio, where he would spend a solid 4 years in Calabria, all in Italy's top flight.
In 2007, despite having a successful spell in Calabria, Tedesco transferred to Sicilian side Calcio Catania.
On 9 July 2009, Tedesco was very surprisingly sold to Bologna FC who have signed the midfielder from Calcio Catania on a two-year deal.
After almost three and a half years without a job, Igea Virtus appointed Tedesco as their new manager on 24 October 2018.