For thirty years, he presided over the political science faculty of Milan's Università Cattolica (Catholic University).

[3] The supporters of Umberto Bossi's party called him Prufesùr (the Professor), a Lombard nickname to remember his role.

Inspired by Max Weber and Carl Schmitt, Miglio's works have analysed prevailing power structures in politics, parliamentarianism and bureaucracies.

An advocate of federalism, Miglio grew even more radical in his later years, moving to a confederal or even secessionist and libertarian standpoint, in part due to his readings of Étienne de La Boétie and Henry David Thoreau.

[4][5][6][7][8] Some of Miglio's work has been published in English by the journal Telos, but the bulk of his opus has never been translated from Italian.