[3] Additionally, Buendia is a Spanish surname from an interjection of the phrase buenos días, meaning "good morning".

Its segment from Roxas Boulevard to the zipper lane of Magdalena Jalandoni Street is alternatively known as Spine Road, while its segment from thereon to Atang Dela Rama Street is alternatively known as Manila Film Center Main Road, after the Manila Film Center.

On July 26, however, Makati mayor Abby Binay ordered the removal of these signs, citing that city officials had approved the stunt without her knowledge, stating that the request would have been rejected had it reached her office.

After its intersection with Osmeña Highway, it becomes divided by a center island once again for the rest of its route as it traverses the Makati Central Business District.

[14] It was extended westward to the Manila Bay shoreline, occupying the former Calle Ochoa in Pasay and eastward to the former Nielson Field in Makati.

[15] Subsequently, it was extended to the present-day Bay City reclamation to the west and EDSA to the east, following the development of the Makati Central Business District.

[2] In 2014, under the Roadmap for Transport Infrastructure Development for Metro Manila and Its Surrounding Areas (Region III & Region IV-A; also known as the Metro Manila Dream Plan), the Japan International Cooperation Agency (JICA) study proposes a dual 2-lane elevated expressway from the intersection of Roxas Boulevard and this road to the intersection of C-5 and Kalayaan Avenue for about 9.3 kilometers (5.8 mi).

[19] Gil Puyat Avenue in Pasay is the site of Networld Hotel Spa and Casino, World Trade Center Manila, and the CCP Open Grounds.

Green Frog Transport Corp. operates hybrid buses serving the route between Gil Puyat and Kalayaan Avenue and the bus transit between Parañaque Integrated Terminal Exchange and Bonifacio Global City.

[20][21] Provincial buses with terminals along the avenue's section in Pasay, as well as regular and air-conditioned jeepneys, also serve the route.