It stretches across western Metro Manila from Roxas Boulevard in Pasay to Epifanio de los Santos Avenue (EDSA/C-4) in Makati.

[4][5] This section passes through some of the most important Pasay landmarks, such as the Cuneta Astrodome, Cartimar shopping district and Santa Clara de Montefalco Parish.

East of Osmeña Highway, the avenue enters the Makati Central Business District, where it merges with traffic from a Skyway ramp near the Amorsolo Street junction.

[8] It soon ends at a traffic light intersection with Osmeña Highway in Pio del Pilar, near the Pasay Road PNR station.

Past Amorsolo Street, it crosses Paseo de Roxas near Greenbelt and Makati Avenue near Glorietta until it ends at a traffic light intersection with EDSA.

[10] The present avenue originated from an old street linking the coast of Manila Bay in Pasay to Barrio Culi-Culi (now Barangay Pio del Pilar) in San Pedro de Macati.