It is one of the busiest roads in Metro Manila, crossing through the heart of the Makati Central Business District.

[3][4][5] The airport was destroyed during the Japanese occupation of the Philippines on December 10, 1941, and resumed operations after the end of World War II in 1947.

[15][16][17] On February 12, cycling groups opposed to the scheme organized a protest bike ride along Ayala Avenue.

In response, Make It Makati deferred the implementation of the sharrows scheme to March 6 to gather feedback and engage in dialogue with the cycling community.

Ayala Corporation, its subsidiaries and affiliates, in addition to many multinational companies, banks and other major businesses, are located within the triangle.

A few upscale boutiques, restaurants and a park called Ayala Triangle Gardens are also located in the area.

[25] From August 2000 to January 2001, Ayala Avenue became the focal point for protests once again, this time against President Joseph Estrada, who later resigned upon being deposed during the Second EDSA Revolution.

[27] On September 8, 2023, climate activists held a protest in front of the Ninoy Aquino Monument at the intersection of Ayala Avenue and Paseo de Roxas to urge, notably, G20 world leaders to shift from fossil fuels to renewable energy.

[28] On June 26, 2024, members of the Asian Peoples' Movement on Debt and Development held a protest calling for a halt to debt-related policies.