Gilles Klopman

His notable contributions to the theory of chemical reactivity include the development of the Klopman–Salem equation, first described independently by him and Lionel Salem in 1968.

His research, titled "Structure-Activity Studies of Biologically Active Molecules," focused on evaluating chemical reactivity.

His work, widely used to explain ambident selectivity of nucleophiles, links linear free energy type correlations to more fundamental chemical concepts.

In the realm of quantum mechanics and computers, he designed and programmed the first semi-empirical method for calculating the properties of saturated molecules, later known as MINDO.

Furthermore, his work has contributed to developing quantitative relationships between the nature and intensity of odors and their chemical structure for the perfume industry (adapted from the CWRU website for the Department of Chemistry).