Giorgio Gusmini (9 December 1855 – 24 August 1921) was a Cardinal of the Roman Catholic Church who served as Archbishop of Bologna.

He was transferred to serve as the Professor of letters, philosophy and history at Collegio San Alessandro, Bergamo, where he stayed until 1890.

He was created Privy chamberlain supra numerum on 16 December 1901 and was reappointed on 20 October 1903.

He spent four years in Foligno, until he was promoted to fill the vacancy in the metropolitan see of Bologna that resulted from the elevation of Giacomo della Chiesa to the Papacy.

He was created and proclaimed Cardinal-Priest of Santa Susanna in the first consistory of the newly elected pope, Benedict XV that was held on 6 December 1915.