From 1458 to the Cardinal's death in 1464 he had served Cusanus as a secretary at Rome, where he helped his master edit a ninth-century manuscript of the Opuscula and other works of Apuleius.
[2] From 1468 Bussi was the chief editor for the printing house of proto-typographers Arnold Pannartz and Konrad Sweynheim, after they moved it from Subiaco to Rome.
Though his edition of Pliny was not the first (a 1469 printing at Venice preceded it), nonetheless it was criticised by Niccolò Perotti in a letter to Francesco Guarneri, secretary of cardinal-nephew Marco Barbo.
[8] Bussi dedicated most of his editions to Pope Paul II, whom he served as the first papal librarian, as Perotti assumed his former position as press editor for Sweynheym and Parnnatz (1473).
In 1472 he requested assistance for Sweynheim and Pannartz from Pope Sixtus IV, since the printers, who typically published 275 copies in a single edition, had an enormous unsold stock.