[1] In 1466 he was engaged as a sculptor, with his brother Protasio, by Duke Galeazzo Maria Sforza to work at the famous Certosa, near Pavia.
Amadeo also designed the funerary monument to Medea Colleoni, which was intended for the church of Santa Maria della Basella in Urgnano.
In 1480 he finished the arch of the Persian Martyrs in the Olivetani Monastery of Cremona (four marble reliefs remain today, dated 1484).
On the death of Guiniforte Solari in 1481, Amadeo had been temporarily appointed to succeed him as head architect of the Certosa, and was commissioned to make a fresh design for the façade, with the assistance of Benedetto Briosco, Antonio della Porta, and Stefano di Sesto.
In 1485 he collaborated with his brother-in-law Pietro Antonio Solari in the Ospedale Maggiore of Milan, a project of which he was made director ten years later.
[2] In 1488 Amadeo was commissioned by Cardinal Ascanio Sforza, to become director of works of the new Pavia Cathedral, again with Bramante having a minor role.
In 1982[6] it had been proven that the Sanctuary of Santa Maria alla Fontana in Milan, attributed for many years to Leonardo da Vinci was in fact designed by Amadeo.