The current church was instead built from 1472 to 1482 under commission from Duchess Bona di Savoia and Duke Gian Galeazzo Sforza.

However, recent documents prove that Bramante had a minor role, with most of the work being attributable to Giovanni Antonio Amadeo, who designed the façade.

According to sources attributing the entire chapel to Bramante, Agostino de Fondulis included a terracotta bust of the architect.

The ancient sacellum of San Satiro was also covered with cotto decoration and enriched with a terracotta portraying the Dead Christ by Agostino de Fondulis.

The choir, which had to be truncated a depth of only 90 cm (3.0 ft) due to the presence of the road Via Falcone behind the church, was replaced by Bramante with a painted perspective, realizing in this way one of the first examples of trompe-l'œil in the history of art.