In 1456 the Duke of Milan, Francesco Sforza, founded the Magna Domus Hospitalis (Ca' Granda), a hospital dedicated to Annunciata (a municipality of the province of Brescia, Northern Italy).

Designed by the renowned architect Filarete and built by the engineer Guiniforte Solari (responsible for the courtyard of the Certosa di Pavia, a monastery complex in Lombardy, Northern Italy), the hospital formed part of the completion of the reform of hospitals started by the Archbishop Rampini in the years of the Golden Ambrosian Republic.

The Ospedale Maggiore moved to a vast area between the streets of Francesco Sforza (the site of the canal), Porta Romana, Lamarmora and Commenda.

The university has hosted prominent medical doctors and experts including:[1] The organisation's insignia used to bear the scene of the Annunciation and the Latin motto 'ave gratiae plena' ("hail, full of grace").

The heraldic representation, still the basis of the Foundation's current logo, is closely linked with the Visconti symbol of the flaming, radiant turtle-dove.

The project and its realisation were the responsibility of the Milanese architect Giò Ponti, who intended to add value to the banner using both materials and techniques.

The banner was inaugurated by Cardinal Ildefonso Schuster on 24 March 1935 (the first day of the Festival of Forgiveness) during a solemn function held in Milan's Duomo.

Today, the mummy can be found at Sforza Castle, while the papyrus is housed in the Historical Archive of the General Hospital.

The scroll, almost seven metres long, was produced in Thebes for the scribe and designer Pthamose at the beginning of the nineteenth dynasty of Egypt (1305-1200 BC).

It shows a complete text, full of drawings, and it mentions a series of formulae to activate several amulets, which is rare in similar papyri.

The Ospedale Maggiore General Hospital- Mangiagalli- Regina Elena Foundation, has two executive committees which are divided into separate departments.

It caters toover 20 million inhabitants in Lombardy, Liguria, Veneto, Friuli-Venezia Giulia, Marche and the Autonomous Province of Trento.

The main functions of CIR, which operates operating 24/7, are: The hospital also hosts Bank of Donated Human Milk, a Biobank for the cryoconservation of seminal fluid and muscle tissue, peripheral nerve, DNA and cell culture[13] which exchange valuable biological samples with National and International Institutes both for diagnostic and scientific research purposes.