He was born in San Marino on September 27, 1506, and at 18 years of age was sent by his father to Bologna, to learn commerce under Bastiano di Ronco, a merchant of the Guild of Wool.
The couple lived with Girolamo Genga, from whom Giovanni learned architecture.
In 1543, Giovanni entered into the service of Cosimo I de' Medici, Grand Duke of Tuscany, as an engineer.
He designed fortifications for Florence, Pistoia, Pisa and San Miniato and also wrote a book on military architecture.
He was wounded in the siege of Montalcino and was killed by enemy fire in a fortress of Aiuola.