Giovanni Domenico de Cupis (Cupi, Cuppi) (1493–1553) was an Italian Cardinal, created by Pope Leo X in the consistory of 1 July 1517.
[1] He was a friend of Ignatius Loyola.
[2] His mother was Lucrezia Normanni, who had had a daughter Felice della Rovere by Pope Julius II before marrying Bernardino de Cupis, Giovanni Domenico's father.
He owed early advancement as Bishop of Trani to Julius.
Dean of the College of Cardinals in 1541.