Giovanni Giacomo Panciroli

He became an advocate to the Roman Curia and then accompanied Giovanni Battista Pamphili (later Pope Innocent X) during his service as nuncio to Naples and Spain.

When he returned to Rome, he entered the service of the Barberini (Francesco and Antonio, nephews of Pope Urban VIII).

The resignation increased Panciroli's role, which enjoyed an authority in the Curia unusual for a minister not a blood relative of the Pope, even for a secretary of state, a position still far from taking on the importance that would later have.

When Innocent X asked the Secretary of State for a recommendation regarding a replacement for his woefully incompetent Cardinal-nephew, Francesco Maidalchini.

Upon Panciroli's death, the position was filled by Fabio Chigi who was later elected to the papal throne as Pope Alexander VII.