The tensions led in 1054 to a serious rupture between the Greek East and Latin West called the East–West Schism, which while not in many places absolute, still dominates the ecclesiastical landscape.
Pope Innocent III, who was not involved, initially spoke out against the Crusade, writing in a letter to his legate, "How, indeed, is the Greek church to be brought back into ecclesiastical union and to a devotion for the Apostolic See when she has been beset with so many afflictions and persecutions that she sees in the Latins only an example of perdition and the works of darkness, so that she now, and with reason, detests the Latins more than dogs?
[4] The continuing threat of a Catholic Crusade to restore the Latin Empire, championed by the ambitious Charles I of Anjou, led to the first attempts, on the Byzantine side, to effect a Union of the Churches.
After the Union of Lyon (1274), John Bekkos was installed as a Greek Catholic Patriarch of Constantinople in 1275, but that did not affect the position of Pantaleonе Giustinian.
in 1286, Latin Patriarch Pantaleonе Giustinian was succeeded by Pietro Correr who was the first holder of that office in a new form of a titular see.