The fine quality of Malipiero's lyric voice soon attracted the attention of impresarios, and he was invited to sing at principal venues throughout Italy, including the Teatro Costanzi in Rome, La Fenice in Venice and the Verona Arena.
In 1937, he made the first of what would prove to be many appearances at Italy's foremost opera house, the Teatro alla Scala in Milan, as Ramiro in Rossini's La cenerentola.
Nine years later, following World War II, he took part in an historic concert held to mark the re-opening of La Scala, performing under the baton of Arturo Toscanini.
Much admired in parts written by the bel canto composers Rossini, Donizetti and Bellini, Malipiero was also acclaimed for his performances in Verdi's La traviata, Falstaff and Rigoletto.
Other Italian operas in which he sang with considerable successes included Puccini's La bohème, Manon Lescaut and Gianni Schicchi, and Boito's Mefistofele.