He then moved to Rome and entered positions of leadership within the Vatican hierarchy by the mid 1740s, serving as Auditor of the Camerlengo from 1748 to 1759.
While living in Rome, he was named by Pope Clement XIV as President of the Pontifical University of Ferrara from 1763 to 1781.
He was an avid collector of books, artworks, and antiquities; and donated his collection to institutions in the city.
He is said to have played a role in 1754, while magistrate of the Camerlengo along with Cardinal Valenti Gonzaga and the painter Francesco Mancini (the then-Principe of the Academy of St Luke) in establishing an Accademia del Nudo inside the Vatican under the protection of Cardinal Girolamo Colonna during the papacy of Benedict XIV.
[3] He was the owner of a lithotheque or stone sampler, now on display in the Musei Civici di Arte Antica in Ferrara.