Born in Alessandria, he was released from his familial bonds (patria potesta) in 1453 when he is documented to have established a workshop in Genoa.
[2] His first documented piece is from 1463 for a relief carving of a chapel's altar in Genoa Cathedral, at which time he would have met Vincenzo Foppa who came to Liguria as specified by that contract, and who would later influence Mazone's style.
His Annunciation polyptych, now held at Santa Maria di Castello shows Netherlandish influences, particularly in the rendering of the central panel.
[1] Jan van Eyck's portable altarpiece, the Dresden Triptych, was in Liguria in Italy by the end of the 15th century, and apparently influenced Mazone's style.
His 1489 Nativity, painted for the Sistine Chapel shows a complete break with Netherlandish influences and a movement toward a Paduan style.