The road connects the junction of St Clements and Marston Road with the suburb of Headington, up Headington Hill.
Also to the south on Gipsy Lane at the top of Headington Hill is the Headington campus of Oxford Brookes University, originally the Oxford Polytechnic.
Pullens Lane leads off to the north at the top of Headington Hill.
[1] Headington Road is the home of the Oxford Spanish Civil War memorial which is dedicated to local residents who travelled to Spain to join the International Brigades to fight against fascist forces backed by Hitler and Mussolini during the Spanish Civil War (1936-1939).
During the Spanish Civil War, 29 British people with connections to Oxfordshire joined the International Brigades, with a further two who joined POUM.